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Improve your performance, protect your brain and upgrade your sleep.

Three Pack

De 3-pack bestaat uit alle drie producten van BrainBullets. De drie formules zijn specifiek gemaakt zodat ze dagelijks samen genomen kunnen worden. De formules vullen elkaar aan en werken in synergie. De 3-pack is de ultieme toevoeging aan uw levensstijl.

caffeine improves attention, alertness and working memory.

  • Einöther, S.J.L. and Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology, 225: 251.

Tyrosine is dietary precursor of dopamine and tyrosine supplementation can aid cognitive measurements after sleep deprivation.

  • Adrian Hase, Sophie E. Jung, Marije aan het Rot. (2015). Behavioral and cognitive effects of tyrosine intake in healthy human adults, Pharmacology Biochemistry and Behavior, Volume 133, Pages 1-6.
  • Neri, DF., Wiegmann, D., Stanny, RR., Shappell, SA., McCardie, A., McKay, DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, Space and environmental medicine. 66(4):313-9.

L-theanine improves selective attention and alertness. While doing this it also promotes relaxation without causing drowsiness. L-theanine counterbalances increased blood pressure and vascular restriction caused by caffeine supplementation.

  • Lekh Raj Juneja, Djong-Chi Chu, Tsutomu Okubo, Yukiko Nagato, Hidehiko Yokogoshi. (1999). L-theanine—a unique amino acid of green tea and its relaxation effect in humans, In Trends in Food Science & Technology, Volume 10, Issues 6–7, Pages 199-204
  • Chanaka, N., Kahathuduwa, Tharaka L. Dassanayake, A. M. Acute effects of theanine, caffeine and theanine–caffeine combination on attention. Nutritional Neuroscience Vol. 20 , Iss. 6.
  • Janet Bryan. (2008) Psychological effects of dietary components of tea: caffeine and L-theanine, Nutrition Reviews, Volume 66, Issue 2, Pages 82–90

DMAE stimulates production of acetylcholine which is the primary neurotransmitter involved in learning. In addition, DMAE can act as an antioxidant and.

  • Vijay K. Kapoor, Janhvi Dureja, Renu Chadha, Synthetic drugs with anti-ageing effects, In Drug Discovery Today, Volume 14, Issues 17–18, 2009, Pages 899-904, ISSN 1359-6446.
  • Gabriela Malanga, Maria Belen Aguiar, Hugo D. Martinez, Susana Puntarulo. (2012). New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger. Drug Metabolism Letters. Volume 6 , Issue 1.

Vitamin B6 serves as a coenzyme in a variety of enzymatic reactions in the metabolism of amino acids, lipids and neurotransmitter biosynthesis. Vitamin B6 reduces tiredness and fatigue and can help maintain cognitive health in ageing.

Vitamin B12 contributes to normal neurological and psychological functions. In addition, it has been shown to reduce tiredness and fatigue

Guarana extract can improves cognitive performance and reduces mental fatigue associated with sustained mental effort.

  • D.O. Kennedy, C.F. Haskell, B. Robertson, J. Reay, C. Brewster-Maund, J. Luedemann, S. et al. (2008). Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana), In Appetite, Volume 50, Issues 2–3, Pages 506-513,
  • D.O. Kennedy, C.F. Haskell, K.A. Wesnes, A.B. Scholey,. (2004). Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacology Biochemistry and Behavior,Volume 79, Issue 3, Pages 401-411

Citicoline is a cognitive enhancing and neuroprotective compound that improves attention and psychomotor speed. It is important for neuron structure and aids in neuronal membrane repair.

 

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Blueberry extract contains anti-oxidant and anti-inflammatory compounds such as flavonoids and anthocyanins. The overall reduced risk of cognitive decline that has been observed with higher intakes of fruit and vegetables is likely attributable to a higher intake of flavonoids.

 

Alpha lipoic acid is a natural neuroprotective compound with antioxidant and anti-inflammatory properties. It improves mitochondrial function and elevates the activities of antioxidants such as vitamin E.

 

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Low vitamin D3 levels are associated with increased rates of cognitive impairment and increased risk for neurodegenerative disease. Vitamin D3 supplementation has been shown to improve visual memory.

Vitamin E is a plant-derived antioxidant that is important for neurological health. Vitamin E protects neurons from damage through its anti-oxidant properties.

 

Vitamin K2 is found in all brain regions is important for neuronal cell structure. It protects the brain from oxidative stress and inflammatory processes, two phenomena that are associated with age associated neurodegenerative diseases.

 

Melatonin helps to reduce the time to fall asleep and can be used to adjust sleep patterns.

  • Amnon Brzezinski, Mark G. Vangel, Richard J. Wurtman, Gillian Norrie, Irina Zhdanova, Abraham Ben-Shushan, Ian Ford, Effects of exogenous melatonin on sleep: a meta-analysis, In Sleep Medicine Reviews, Volume 9, Issue 1, 2005, Pages 41-50, ISSN 1087-0792.

L-tryptophan improves sleep latency but does not limit cognitive performance. (L-tryptophan is the building block for important sleep regulatory molecules such as melatonin.)

  • Richard, D. M., Dawes, M. A., Mathias, C. W., Acheson, A., Hill-Kapturczak, N., & Dougherty, D. M. (2009). L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. International Journal of Tryptophan Research : IJTR, 2, 45–60.

L-theanine is shown to reduce stress and anxiety.

  • Keiko Unno, Naoki Tanida, Naoto Ishii, Hiroyuki Yamamoto, Kazuaki Iguchi, Minoru Hoshino, Atsushi Takeda, Hayato Ozawa, Tsutomu Ohkubo, Lekh Raj Juneja, Hiroshi Yamada. (2013). Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress, In Pharmacology Biochemistry and Behavior, Volume 111, Pages 128-135, ISSN 0091-3057.

Magnesium improves subjective measures of insomnia such as improved sleep efficiency, sleep time and sleep latency.

  • Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2012;17(12):1161-1169.

Vitamin B6 is a co-factor in the production of serotonin and melatonin. Both serotonin and melatonin are important for the sleep regulatory system.

  • Brown MJ, Beier K. Vitamin, B6 (Pyridoxine), Deficiency. [Updated 2017 Dec 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470579/

Zinc in combination with melatonin and magnesium improves sleep latency, sleep quality and total sleep time. In addition, it decreases morning drowsiness.

  • Rondanelli, M., Opizzi, A., Monteferrario, F., Antoniello, N., Manni, R. and Klersy, C. (2011), The Effect of Melatonin, Magnesium, and Zinc on Primary Insomnia in Long-Term Care Facility Residents in Italy: A Double-Blind, Placebo-Controlled Clinical Trial. Journal of the American Geriatrics Society, 59: 82–90. doi:10.1111/j.1532-5415.2010.03232.