Core | 15 caps

17,50

Core will help protect the brain from free radicals and inflammation. In addition, Core improves memory and contains essential vitamins to support healthy brain function. Core is a nootropic that should be taken on a daily basis.

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Description

PROTECT YOUR BRAIN

PROTECT YOUR BRAIN

Who?

Core is made for everyone who is conscious about brain health and everyone who wants to optimize their memory. Core helps students, professionals and older people who struggle with attention and focus. At the same time Core offers daily protection and supplies the brain with essential vitamins.

Why?

There are many potential threats to a healthy brain. Luckily, through scientific research multiple substances which have the ability to protect the brain have been found. The ingredients in Core are selected to offer protection from oxidation, inflammation and vitamin deficiencies. In addition, the ingredients in Core improve memory.

Ingredients per serving size (1 capsule)

Citicoline is a cognitive enhancing and neuroprotective compound that improves attention and psychomotor speed. It is important for neuron structure and aids in neuronal membrane repair.

Blueberry extract contains anti-oxidant an anti-inflammatory compounds such as flavonoids and anthocyanins. The overall reduced risk of cognitive decline that has been observed with higher intakes of fruit and vegetables is likely attributable to a higher intake of flavonoids.

Alpha lipoic acid is a natural neuroprotective compound with antioxidant and anti-inflammatory properties. It improves mitochondrial function and elevates the activities of antioxidants such as vitamin E.

Low vitamin D3 levels are associated with increased rates of cognitive impairment and increased risk for neurodegenerative disease. Vitamin D3 supplementation has been shown to improve visual memory.

Vitamin E is a plant-derived antioxidant that is important for neurological health. Vitamin E protects neurons from damage through its anti-oxidant properties.

Vitamin K2 is found in all brain regions is important for neuronal cell structure. It protects the brain from oxidative stress and inflammatory processes, two phenomena that are associated with age associated neurodegenerative diseases.

How?

The brain is a complex machine exposed to many endogenous threats. Neuro inflammation can result in impaired cognition and even depression. Substances being able to reduce inflammation can be useful in protecting the brain. Besides harmful inflammation, our brain is exposed to reactive oxygen species (ROS), the so-called free radicals. These are molecules produced in every organism during metabolism. Free radicals can damage components of cells including DNA. Antioxidants can reduce the amount of free radicals and thus protect the body and brain from damage. The ingredients in Core are carefully chosen, taking into consideration the harmful effects of free radicals and inflammation.

Alpha Lipoic Acid (ALA) is the first ingredient used in the Core formula. ALA can be found in certain types of food, such as broccoli and organ meat, but the concentration is too low to make a considerable difference [1, 2]. After supplementation, ALA crosses the blood brain barrier effectively and exerts antioxidant effects both intra and extracellular [3, 4, 5, 6, 7]. In addition to the strong antioxidant effects, ALA displays anti-inflammatory properties [8].

The second ingredients used in the Core formula is citicoline and this is arguably one of the most commonly known and well researched nootropics. Citicoline is taken up very effectively by the body and is then converted into choline. Choline is an essential nutrient, meaning it has to be obtained from the diet or supplementation in order to maintain health [9]. Choline is a precursor to acetylcholine, which is an important neurotransmitter in regard to attention, learning and memory [9]. Citicoline has been shown to improve several cognitive measurements, including ones related to attention and memory. Besides, citicoline is neuroprotective, as it is used for the production of phosphatidylcholine, a major phospholipid in the brain that aids in neuronal membrane repair [10, 11, 12].

The third ingredient in the Core formula is blueberry extract. Blueberry extract contains several classes of chemicals commonly found in plants, among them flavonoids and anthocyanins. These compounds are thought to protect the brain by exerting antioxidant and anti-inflammatory effects. Greater intakes of blueberries and strawberries is associated with slower rates of cognitive decline [13].

Lastly, the Core formula contains three vitamins that are important in regard to cognition. Cholecalciferol (vitamin D3) supplementation is shown to improve visual memory [14]. Low vitamin D3 levels are associated with worse cognitive performance and cognitive decline [15]. The correlation between cognitive deterioration and low vitamin D3 is further substantiated by numerous studies indicating the relation between low vitamin D3 levels and certain neurodegenerative diseases. Multiple sclerosis is a neurological and proinflammatory condition that causes the damage to the myelin sheath of neurons. MS prevalence is affected by geographic and more specifically latitude [16]. Latitude is thought to play a role in the prevalence of MS because it affects the exposure to the amount and intensity of sunlight and consequently vitamin D levels. Furthermore, there is a weak correlation between Alzheimer’s disease and vitamin D3 levels [17, 18]. As a final point, high vitamin D3 levels are associated with reduced risk of Parkinson’s disease [19, 20, 21].

The second vitamin used in the formula is α-tocoferol (vitamin E) and this is a plant-derived antioxidant that is essential for human health [22]. The critical involvement of vitamin E in the maintenance of neurological health has been recognized for over 50 years. Vitamin E is thought to exerts its neuroprotective effects by working as an antioxidant and neutralizing unstable lipid peroxy-radicals which are generated during fatty acids degradation [23]. It has been shown that vitamin E has the ability to protect neurons from oxidative stress in vivo and in vitro [24, 25, 26, 27]. Vitamin E intake, from foods or supplements, is associated with reduced cognitive decline during aging [22]. Recent studies implicate abnormal vitamin E status in multiple disorders of the central nervous system, including those that impair memory, learning, and emotive responses [28].

The third vitamin used in the Core formula is menaquinone (vitamin K2). Vitamin K2 is found in all brain regions and it involved in numerous neurological processes. Vitamin K‐dependent proteins (VKDP), as their name implies, need vitamin K2 to perform their enzymatic role. Gas6 is an example of such a protein and is found in the nervous system. This enzyme is involved in functions such as cell survival, chemotaxis, mitogenesis, cell growth, and myelination [29]. Another important role of vitamin K2 is, that it is needed for the biosynthesis of sphingolipids. Sphingolipids are a group of complex lipids present in all cells and they are major components of cell membranes [30]. They are present in particularly high concentrations in cells of the central nervous systems. Initially appreciated for their structural role, sphingolipids are now viewed as key players of important cellular events such as proliferation, differentiation, senescence, cell-cell interaction, and transformation [31]. Furthermore, research conducted in recent years have linked alterations in sphingolipid metabolism to the aging process [32]. Lastly, both in vitro, animal and human epidemiological studies point to protective roles of vitamin K2 against oxidative stress and inflammatory processes, two phenomena that are associated with age associated neurodegenerative diseases [33, 34, 35, 36, 37, 38, 39, 40].

Sources + Links

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40. Li, J., O, W., Li, W., Jiang, Z.-G., & Ghanbari, H. A. (2013). Oxidative Stress and Neurodegenerative Disorders. International Journal of Molecular Sciences, 14(12), 24438–24475.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876121/

PROTECT YOUR BRAIN